Ku-70 Polyclonal Antibody, 100ul[BT-AP04893] Culture Media Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding different isoforms have been found in this gene

Belongs to the krueppel C2H2-type zinc-finger protein family

This gene encodes the phosphatase 2A catalytic subunit

The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest

It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins

Ku-70 Polyclonal Antibody, 100ul[BT-AP04893] Culture Media Alternatively spliced transcript variants encodingThe p70 p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single stranded DNA dependent ATP dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with