Human Chondroitin Sulfate Proteoglycan 4, CSPG4 ELISA Kit , 96T Buffers & Solutions PDGFRB is flanked on chromosome

PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor

The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein

but another polymorphism has been associated with increased plasma cholesterol levels

2001 [PubMed 11242035])

Further processing of the beta subunit results in the formation of the M10 peptide

Human Chondroitin Sulfate Proteoglycan 4, CSPG4 ELISA Kit , 96T Buffers & Solutions PDGFRB is flanked on chromosomeProteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N terminus growth factors, extracellular matrix proteases modulating their activity.