Raf-1 Polyclonal Antibody, 20ul[BT-AP13531] Antibody Humanization It may also play a

It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation

This gene is intronless and encodes a member of the ubiquitin-conjugating enzyme family

It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation

|cofactor:Binds 3 calcium ions per subunit

Multiple transcript variants encoding different isoforms have been characterized for this gene

Raf-1 Polyclonal Antibody, 20ul[BT-AP13531] Antibody Humanization It may also play aThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.