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p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets This gene encodes a preproprotein

SKU: 21244138705

4.4
SEK108.00 SEK131.00

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p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets This gene encodes a preproproteinThis gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight binding, strong inhibitor of several G1 cyclin Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

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Description

This gene encodes a preproprotein that is proteolytically processed to generate two protein products| megakaryocyte potentiating factor and mesothelin

This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes

Following binding of gonadotropin-releasing hormone

The WW domains are essential for localization to nuclear speckles

Seems to prevent the degeneration of motor axons after axotomy

p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets This gene encodes a preproproteinThis gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight binding, strong inhibitor of several G1 cyclin Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

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