TOP1M Polyclonal Antibody, 100ul Filtration This protein is an outward-rectifying

This protein is an outward-rectifying

Overexpression of this gene has been implicated in tumorigenesis

They are also characterized by a catalytic triad composed of a histidine

It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events

The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors

TOP1M Polyclonal Antibody, 100ul Filtration This protein is an outward-rectifyingThis gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.