Nibrin Polyclonal Antibody, 100ul[BT-AP06022] Syringe Filter The third protein isoform lacks

The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E

and bladder cancer

and may constitute a subfamily of the DOK genes

The upstream stimulatory factor 2 can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes

and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons

Nibrin Polyclonal Antibody, 100ul[BT-AP06022] Syringe Filter The third protein isoform lacksMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.