PDK1(Phospho Ser241) Polyclonal Antibody, 20ul Protein Post-translational Modification The cytogenetic location of this

The cytogenetic location of this locus has been reported as both 8p11 and 8q11

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The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells

and to a lesser degree

Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia

PDK1(Phospho Ser241) Polyclonal Antibody, 20ul Protein Post-translational Modification The cytogenetic location of thisCatalytic activity: ATP + a protein = ADP + a phosphoprotein.,Phosphorylates and activates not only PKB AKT, but also PKA, PKC zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.,PTM: Phosphorylated on tyrosine and serine threonine. Phosphorylation on Ser 241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser 241,