PAK alpha/beta / gamma(Phospho Thr423/402/421) Polyclonal Antibody, 100ul DNA Fragments MAPK activation cascades mediate various

MAPK activation cascades mediate various physiologic processes| including cellular proliferation| apoptosis| differentiation| and stress responses (summary by Patterson et al

The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like)| being able to form cytosolic complexes with NF-kappa B| trapping it in the cytoplasm

establishing its role in vascular disease

The gene is involved in a chromosomal translocation t(14

A soluble form of this protein can bind to dendritic cells and inhibit their maturation

PAK alpha/beta / gamma(Phospho Thr423/402/421) Polyclonal Antibody, 100ul DNA Fragments MAPK activation cascades mediate variousThis gene encodes a family member of serine threonine p21 activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this