Phospho-Akt1/3 (Y437/434) Polyclonal Antibody, 100ul Biomatrix The 700-kD eukaryotic translation initiation

The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits

• Temperature range -20℃ to 40℃

Belongs to the CDC50/LEM3 family

subunit:Interacts with O-GlcNAc transferase

These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al

Phospho-Akt1/3 (Y437/434) Polyclonal Antibody, 100ul Biomatrix The 700-kD eukaryotic translation initiationThe serine threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3 kinase. In the developing nervous system AKT is a