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RELN Polyclonal Antibody, 50ul Vortex Mixer The encoded protein| whose degradation

SKU: 23661859874

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RELN Polyclonal Antibody, 50ul Vortex Mixer The encoded protein| whose degradationThis gene encodes a large secreted extracellular matrix protein thought to control cell cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two

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Description

The encoded protein| whose degradation is induced in a proteasome-dependent manner by MDM2| is a membrane-bound protein that has been shown to associate with EPS15| LNX1| and NOTCH1

The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells

Mutations in SLC4A11 have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2

strengthening and stabilizing the pericentriolar region prior to spindle formation

an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7

RELN Polyclonal Antibody, 50ul Vortex Mixer The encoded protein| whose degradationThis gene encodes a large secreted extracellular matrix protein thought to control cell cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two

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