Caspase 2 Rabbit Polyclonal Antibody, 100ul[BT-AP06906] Cellular Function Assays Eight alternatively spliced transcript variants

Eight alternatively spliced transcript variants have been described

GRK7 encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family

and bind SHP2 tyrosine phosphatase and GRB2 adapter protein

the protein binds to iron-responsive elements (IREs)

Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder

Caspase 2 Rabbit Polyclonal Antibody, 100ul[BT-AP06906] Cellular Function Assays Eight alternatively spliced transcript variantsalternative products: Isoforms differ in the N and C termini Catalytic activity: Strict requirement for an Asp residue at P1 with 316 asp being essential for proteolytic activity and has a preferred cleavage sequence of Val Asp Val Ala Asp . Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.