SSRP1 Rabbit Polyclonal Antibody, 20ul Organelle Studies This gene| DEFB106A| represents the

This gene| DEFB106A| represents the more centromeric copy

Transcripts from this gene lack polyA tails| instead

It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes

The protein encoded by this gene is part of the Mediator complex| which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes

For novice experimental personnel

SSRP1 Rabbit Polyclonal Antibody, 20ul Organelle Studies This gene| DEFB106A| represents theThe protein encoded by this gene is a subunit of a heterodimer that along with SUPT16H forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition