Stat5 Polyclonal Antibody, 20ul[BT-AP08635] Protein Post-translational Modification Transcriptional repressor that binds to

Transcriptional repressor that binds to the promoter region of target genes

Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability

the alpha2A subtype inhibited transmitter release at high stimulation frequencies

nterferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5-triphosphate group (PPP-RNA)

see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation

Stat5 Polyclonal Antibody, 20ul[BT-AP08635] Protein Post-translational Modification Transcriptional repressor that binds toStat5 is activated in response to a wide variety of ligands including IL 2, GM CSF, growth hormone and prolactin. Phosphorylation at Tyr694 is obligatory for Stat5 activation. This phosphorylation is mediated by Src upon erythropoietin stimulation. Stat5 is constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL 3, which suggests its involvement in angiogenesis and cell motility.