Ku-70 (Acetyl Lys331) Polyclonal Antibody, 100ul Centrifugal Filter Expansion of an ATTCT repeat

Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia

Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor

these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2

X-linked disorder occurring at a frequency of about 1 in 3

Alternative splice variants that encode different protein isoforms have been described

Ku-70 (Acetyl Lys331) Polyclonal Antibody, 100ul Centrifugal Filter Expansion of an ATTCT repeatThe p70 p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single stranded DNA dependent ATP dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with