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Rb(Phospho Ser249) Polyclonal Antibody, 20ul Dry Bath NOLC1 (Nucleolar And Coiled-Body Phosphoprotein

SKU: 28007484562

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Rb(Phospho Ser249) Polyclonal Antibody, 20ul Dry Bath NOLC1 (Nucleolar And Coiled-Body PhosphoproteinThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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Description

NOLC1 (Nucleolar And Coiled-Body Phosphoprotein 1) is a Protein Coding gene

An increase in apoC-III levels induces the development of hypertriglyceridemia

|tissue specificity:Expressed in ovarian and colorectal cancer cell lines (at protein level)

CYP2R1 encodes a member of the cytochrome P450 superfamily of enzymes

The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels

Rb(Phospho Ser249) Polyclonal Antibody, 20ul Dry Bath NOLC1 (Nucleolar And Coiled-Body PhosphoproteinThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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