BAP1(Phospho-Ser592) Rabbit Polyclonal Antibody, 50ul Cell Culture & Maintenance epigenetic silencing of SFRP genes

epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer

LAMC3 encodes the gamma chain isoform laminin

It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer

This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels

Reduced expression of this gene results in enhanced bone regeneration

BAP1(Phospho-Ser592) Rabbit Polyclonal Antibody, 50ul Cell Culture & Maintenance epigenetic silencing of SFRP genesThis gene belongs to the ubiquitin C terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition the enzyme may be involved in regulation of transcription regulation of cell cycle and growth response to DNA damage and chromatin