SENP7 Polyclonal Antibody, 100ul Vortex Mixer Mice deficient for this gene

Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure

The encoded protein is unique in that its C-terminus is derived from CHARLIE8 transposable element sequence

The encoded protein is also a putative tumor suppressor protein| and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia

This encoded protein may play a role in hematopoiesis

Designed to support the growth of CHO cells

SENP7 Polyclonal Antibody, 100ul Vortex Mixer Mice deficient for this geneThe reversible posttranslational modification of proteins by the addition of small ubiquitin like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO specific proteases, such as SENP7, process SUMO precursors to generate a C terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO conjugated substrates.