TH(Phospho Ser8) Polyclonal Antibody, 100ul Cell Function Analysis The encoded protein is required

The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage

not all variants have been fully described

The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes

The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome

Additional allele specific isoforms

TH(Phospho Ser8) Polyclonal Antibody, 100ul Cell Function Analysis The encoded protein is requiredThe tyrosine hydroxylase encoded by TH is involved in the conversion of tyrosine to dopamine. It is the rate limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.