LIMK-1/2 Polyclonal Antibody, 50ul miRNA / siRNA Synthesis The protein primarily localizes to

The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface

GATA2 (GATA binding protein 2) encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes

It was also found to be an essential component of a non-snRNA spliceosome

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Sequence analysis identified three transcript variants that encode two different isoforms

LIMK-1/2 Polyclonal Antibody, 50ul miRNA / siRNA Synthesis The protein primarily localizes toThere are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein protein interactions. LIM kinase 1 and LIM kinase 2 belong to a small subfamily with a unique combination of 2 N terminal LIM motifs and a C terminal protein kinase