PKC delta(Phospho Ser645) Polyclonal Antibody, 100ul Cell Culture Flasks In undifferentiated osteoblasts it is

In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes

This gene is localized to 11q12| in a cluster of other family members

which suggests its involvement in a regulated signaling process

In response to interferon (IFN)| this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G)| in which this protein acts as a transactivator| but lacks the ability to bind DNA directly

The protein encoded by this gene belongs to the TYR family of protein kinases

PKC delta(Phospho Ser645) Polyclonal Antibody, 100ul Cell Culture Flasks In undifferentiated osteoblasts it isProtein kinase C (PKC) is a family of serine and threonine specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile