Shc(Phospho Tyr349) Polyclonal Antibody, 50ul Sealing Film Potassium voltage-gated channel subfamily H

Potassium voltage-gated channel subfamily H member 1 is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel

This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1

Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction

Alternative splicing of this gene results in several transcript variants which encode different isoforms

Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission

Shc(Phospho Tyr349) Polyclonal Antibody, 50ul Sealing Film Potassium voltage-gated channel subfamily HThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation.