MSH3 Polyclonal Antibody, 100ul Biomatrix The encoded protein is the

The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis

Mutations in this gene cause Gitelman syndrome| a disease similar to Bartter's syndrome| that is characterized by hypokalemic alkalosis combined with hypomagnesemia| low urinary calcium| and increased renin activity associated with normal blood pressure

Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway

This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor

unlike closely related proteins

MSH3 Polyclonal Antibody, 100ul Biomatrix The encoded protein is theDNA mismatch repair protein Msh3 encoded by MSH3 forms a heterodimer with MSH2 to form MutS beta, part of the post replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3 7 repeats have been reported.