TIF1Beta Monoclonal Antibody, 100ul Funnels The protein encoded by CTNNB1

The protein encoded by CTNNB1 (catenin beta 1) is part of a complex of proteins that constitute adherens junctions (AJs)

Aberrations in chromosome 1 are found in a variety of cancers

possibly through the interaction with beta- and gamma-catenin at adherens junctions

Expression of this transcript and protein have been reported in cancer specimens of the breast

Mutations in RRM2B have been associated with autosomal recessive mitochondrial DNA depletion syndrome

TIF1Beta Monoclonal Antibody, 100ul Funnels The protein encoded by CTNNB1The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc binding domains, a RING, a B box type 1 and a B box type 2, and a coiled coil region.