PEN2 Rabbit Polyclonal Antibody, 50ul Plates & Dishes The protein encoded by BAX

The protein encoded by BAX (BCL2 associated X

This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation

and at lower levels in heart

and stimulates interferon gamma production in T-helper type I cells

and monocytes

PEN2 Rabbit Polyclonal Antibody, 50ul Plates & Dishes The protein encoded by BAXPresenilins which are components of the gamma secretase protein complex are required for intramembranous processing of some type I transmembrane proteins such as the Notch proteins and the beta amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta amyloid precursor protein generates neurotoxic amyloid beta peptides the major component of senile plaques associated with