Tau(Phospho Ser519) Polyclonal Antibody, 20ul Insect Expression Noonan syndrome and trisomy 12p

Noonan syndrome and trisomy 12p

Mutations in this gene have been associated with Marinesco-Sjogren syndrome

Further regulation is represented by alternative splicing in the glutamine-rich activation domain

The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain

Tau(Phospho Ser519) Polyclonal Antibody, 20ul Insect Expression Noonan syndrome and trisomy 12pThis gene encodes the microtubule associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia,