TRAP220 Polyclonal Antibody, 50ul[BT-AP09180] Immunoassays where it is involved in

where it is involved in transcriptional regulation

Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3

autosomal dominant progressive external ophthalmoplegia-5

Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases

and a dysmorphic facial appearance

TRAP220 Polyclonal Antibody, 50ul[BT-AP09180] Immunoassays where it is involved inThe activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by MED1 (mediator complex subunit 1) is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1.