Rat Nf-Kappa-B Inhibitor Alpha, NFKBIA ELISA Kit, 96T Reservoirs PubMed: 2$458

PubMed: 2$458

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors

possibly by promoting RHOJ palmitoylation (PubMed: 30158707)

This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor B

and functions as a receptor for angiotensin II

Rat Nf-Kappa-B Inhibitor Alpha, NFKBIA ELISA Kit, 96T Reservoirs PubMed: 2$458Inhibits the activity of dimeric NF kappa B REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (By similarity).