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B12 absorption depends on intrinsic factor binding in the stomach

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Among other cells, our immune system also consists of mast cells, which can release a wide variety of chemical mediators such as: Histamine Interleukins Prostaglandins Cytokines Chemokines When you are exposed to an allergen, toxin, and/or injury, these chemical mediators, especially histamine can be released into your body

Snderhauf et al, 2020

In normal redox balance and low B 6 status, Se-GSH-Px was lower with organic selenium than with inorganic selenium, but both sources of selenium gave equivalent Se-GSH-Px responses when the diet was supplemented with vitamin B 6 (Figure 6)