Bag-3 Polyclonal Antibody, 50ul[BT-AP00819] Cell Culture Flasks This protein may be the

This protein may be the target of oncogenic mutations in breast or ovarian cancer

OAT encodes the mitochondrial enzyme ornithine aminotransferase

Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates

Mutations in this gene or its regulatory region cause hypobetalipoproteinemia| normotriglyceridemic hypobetalipoproteinemia| and hypercholesterolemia due to ligand-defective apoB| diseases affecting plasma cholesterol and apoB levels

It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses

Bag-3 Polyclonal Antibody, 50ul[BT-AP00819] Cell Culture Flasks This protein may be theBAG proteins compete with Hip for binding to the Hsc70 Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45 amino acid BAG domain near the C terminus but differ markedly in their N terminal regions. The protein encoded by this gene contains a WW domain in the N terminal region and a BAG domain in the C terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain