LRBA Polyclonal Antibody, 20ul Gloves The gene is located in

The gene is located in a head-to-head orientation with HARSL on chromosome five

The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function

Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome

Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8

GO annotations related to this gene include metallocarboxypeptidase activity

LRBA Polyclonal Antibody, 20ul Gloves The gene is located inThe protein encoded by this gene is a member of the WDL BEACH WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder