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CD58 Polyclonal Antibody, 100ul[BT-AP01958] Cellular Function Assays Mutations in TRHR have been

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CD58 Polyclonal Antibody, 100ul[BT-AP01958] Cellular Function Assays Mutations in TRHR have beenCoagulation factor II (thrombin) receptor like 3 (F2RL3) is a member of the large family of 7 transmembrane region receptors that couple to guanosine nucleotide binding proteins. F2RL3 is also a member of the protease activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.

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Description

Mutations in TRHR have been associated with generalized thyrotropin-releasing hormone resistance

stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues

and mediate signal transduction from

Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity

and a particular variation in this gene has been associated with obesity and insulin resistance in children

CD58 Polyclonal Antibody, 100ul[BT-AP01958] Cellular Function Assays Mutations in TRHR have beenCoagulation factor II (thrombin) receptor like 3 (F2RL3) is a member of the large family of 7 transmembrane region receptors that couple to guanosine nucleotide binding proteins. F2RL3 is also a member of the protease activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.

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