SIK2 Polyclonal Antibody, 50ul Protein Research This gene encodes the interleukin

This gene encodes the interleukin 1 receptor accessory protein

Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis

Angiogenesis has been shown to be essential for growth and metastasis of solid tumors

Multiple pseudogenes have been identified for this gene

The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores

SIK2 Polyclonal Antibody, 50ul Protein Research This gene encodes the interleukinCatalytic activity: ATP + a protein = ADP + a phosphoprotein.,cofactor: Magnesium.,enzyme regulation: Activated by phosphorylation on Thr 175 by STK11 in complex with STE20 related adapter alpha (STRAD alpha) pseudo kinase and CAB39.,Phosphorylates 'Ser 794' of IRS1 in insulin stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB specific