Cdc25A(Phospho Ser75) Polyclonal Antibody, 50ul[BT-AP07488] Immune Cell Analysis These kelch-like repeats promote substrate

These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex

USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds

Interacts with HPS5 and NISCH

3 and an unprocessed pseudogene has been assigned to 16p12-p11

West Nile virus and dengue virus

Cdc25A(Phospho Ser75) Polyclonal Antibody, 50ul[BT-AP07488] Immune Cell Analysis These kelch-like repeats promote substrateCDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated.