GRK 2(Phospho Ser685) Polyclonal Antibody, 20ul Sampling Tubes calcium/calmodulin- dependent protein kinase II

calcium/calmodulin- dependent protein kinase II

Glycosylation at Asn-113 may occur at a secondary level

and mutations in this gene have been associated with different neuromuscular diseases

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GRK 2(Phospho Ser685) Polyclonal Antibody, 20ul Sampling Tubes calcium/calmodulin- dependent protein kinase IIThe product of this gene phosphorylates the beta 2 adrenergic receptor and appears to mediate agonist specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta adrenergic and related G protein coupled receptors. Abnormal coupling of beta adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.