Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing Eight alternatively spliced transcript variants

Eight alternatively spliced transcript variants have been described

Translocations between MLF1 and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia

This gene contains at least 14 exons| and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons

The protein may also be involved in the pathophysiology of depression

This protein mediates the signals of the bone morphogenetic proteins (BMPs)| which are involved in a range of biological activities including cell growth| apoptosis| morphogenesis| development and immune responses

Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing Eight alternatively spliced transcript variantsThe protein encoded by DOK2 (docking protein 2)is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.