PA26 Polyclonal Antibody, 100ul Serological Pipets Alternative splicing results in multiple

Alternative splicing results in multiple transcript variants that encode different isoforms

Multiple pseudogenes of this gene are located on chromosome 1

Defects in this gene are associated with thrombotic thrombocytopenic purpura

encoding the same protein

Catalytic activity:Specificity close to that of papain

PA26 Polyclonal Antibody, 100ul Serological Pipets Alternative splicing results in multipleSESN1 encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The sestrin 1 mediates p53 inhibition of cell growth by activating AMP activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized