LIMK-2 Polyclonal Antibody, 50ul[BT-AP05021] Subcellular Fractions Mutations in PLCG2 have been

Mutations in PLCG2 have been found in autoinflammation

The mammalian protein contains three amino-terminal hydrophobic domains

The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits

The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras

Catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

LIMK-2 Polyclonal Antibody, 50ul[BT-AP05021] Subcellular Fractions Mutations in PLCG2 have beenThere are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein protein interactions. LIM kinase 1 and LIM kinase 2 belong to a small subfamily with a unique combination of 2 N terminal LIM motifs and a C terminal protein kinase