TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 100ul Serological Pipets A germline mutation of VHL

A germline mutation of VHL is the basis of familial inheritance of VHL syndrome

and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction

After translocation

The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding

Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules

TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 100ul Serological Pipets A germline mutation of VHLCatalytic activity: ATP dependent breakage passage and rejoining of double stranded DNA. enzyme regulation: Specifically inhibited by the intercalating agent amsacrine. Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double strand breaks. miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils whereas prokaryotic enzymes relax only