ECE2 Polyclonal Antibody, 20ul Custom Peptide Synthesis Study of its expression in

Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid

This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells

Members of this family are important during development

Mutations in KRT10 are associated with epidermolytic hyperkeratosis

the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails

ECE2 Polyclonal Antibody, 20ul Custom Peptide Synthesis Study of its expression inThis gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane bound zinc dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin 1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants.