EEA1 Polyclonal Antibody, 50ul Drug Development and Evaluation The protein localizes to the

The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA

while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases

IHC and IF application

The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus

which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization

EEA1 Polyclonal Antibody, 50ul Drug Development and Evaluation The protein localizes to theBinds phospholipid vesicles containing phosphatidylinositol 3 phosphate and participates in endosomal trafficking.