Raf-1(Phospho Ser338) Polyclonal Antibody, 100ul Immune Repertoire Sequencing |PTM:The activation peptide is cleaved

|PTM:The activation peptide is cleaved by factor IXa (in the intrinsic pathway)| or by factor VIIa (in the extrinsic pathway)

A pseudogene of this gene is found on chromosome 1

At the nuclear envelope

a conformational change is induced in the protein which traps the proteinase

this protein activated NF-kappaB and induced the phosphorylation of BCL10

Raf-1(Phospho Ser338) Polyclonal Antibody, 100ul Immune Repertoire Sequencing |PTM:The activation peptide is cleavedThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.