Socius Polyclonal Antibody, 50ul Molecular Weight Markers The PGBD proteins appear to

The PGBD proteins appear to be novel

The protein binds to RNA via two KH domains and also colocalizes with MEX3A| Dcp1A decapping factor and Argonaute proteins within P (processing) bodies

coordinates the addition of a ubiquitin moiety to existing proteins

recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin

The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled| a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin

Socius Polyclonal Antibody, 50ul Molecular Weight Markers The PGBD proteins appear toUBXN11 (UBX domain protein 11) encodes a protein with a divergent C terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C terminal region. It also interacts with several heterotrimeric G proteins through their G alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity