Phospho PKC theta (Y90) Rabbit Polyclonal Antibody, 20ul Antibodies Mutations in BUB1 have been

Mutations in BUB1 have been associated with aneuploidy and several forms of cancer

centrosome separation and establishing a bipolar spindle during cell mitosis

suggesting that it functions as a transcription factor

and may be involved in pancreatic lithogenesis

In addition| this subunit| in combination with several other polymerase subunits| forms the DNA binding domain of the polymerase| a groove in which the DNA template is transcribed into RNA

Phospho PKC theta (Y90) Rabbit Polyclonal Antibody, 20ul Antibodies Mutations in BUB1 have beenCatalytic activity: ATP + a protein = ADP + a phosphoprotein. cofactor: Magnesium. The C1 domain containing the phorbol ester DAG type region 1 (C1A) and 2 (C1B) is the diacylglycerol sensor and the C2 domain is a non calcium binding domain. enzyme regulation: Three specific sites; Thr 538 (activation loop of the kinase domain) Ser 676 (turn motif) and Ser 695 (hydrophobic region) need to be phosphorylated for its full activation. PKC is activated by