GPNMB Polyclonal Antibody, 20ul PCR Series it is seen within the

it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration

and RUNX3 is frequently deleted or transcriptionally silenced in cancer

May act as a zinc-influx transporter

Involved in apoptotic release of cytochrome c

have been described for this gene (PMID: 18089847)

GPNMB Polyclonal Antibody, 20ul PCR Series it is seen within theThe protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for