NTCP2 Rabbit Polyclonal Antibody, 20ul Serological Pipets Members of this family are

Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions

This is the rate-limiting step in the de novo synthesis of guanine nucleotides

The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation| apoptosis| differentiation| the stress response| and regulation of immune genes

and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction

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NTCP2 Rabbit Polyclonal Antibody, 20ul Serological Pipets Members of this family areThis gene encodes a sodium bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines