Rb(Phospho-Ser807/811) Rabbit Polyclonal Antibody, 100ul Plasmid Preparation Several transcript variants encoding two

Several transcript variants encoding two different isoforms have been found for this gene

helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa

Dual specificity mitogen-activated protein kinase kinase 2 is known to play a critical role in mitogen growth factor signal transduction

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which is thought to interact with KAP1

Rb(Phospho-Ser807/811) Rabbit Polyclonal Antibody, 100ul Plasmid Preparation Several transcript variants encoding twoThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB) bladder cancer and osteogenic sarcoma.