SOCS-3 Monoclonal Antibody, 50ul Serological Pipets This gene is part of

This gene is part of a cluster of similar genes on chromosome 3

suggesting an involvement in the regulation of processes such as cell survival

also referred to as Bruton's disease

the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway

An important paralog of this gene is TBPL1

SOCS-3 Monoclonal Antibody, 50ul Serological Pipets This gene is part ofThis gene encodes a member of the STAT induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN) gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse