Cortactin(Phospho Tyr421) Polyclonal Antibody, 20ul Centrifugal Filter Inflammatory stimuli can induce IKK-mediated

Inflammatory stimuli can induce IKK-mediated phosphorylation of PIAS1 at Ser90

The protein encoded by this gene shares similarity with several thiamine pyrophosphate-binding proteins identified in bacteria| yeast| and plants

The encoded protein may be involved in cell survival and proliferation| and is associated with several disease states including cancer and Alzheimer's disease

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The D4Z4 repeat is polymorphic in length

Cortactin(Phospho Tyr421) Polyclonal Antibody, 20ul Centrifugal Filter Inflammatory stimuli can induce IKK-mediatedThis gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase