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Mutations in this gene may underlie hereditary disorders of balance and hearing

while CUL-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes

Regulates myosin phosphatase activity

It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation

Parkin Polyclonal Antibody, 100ul Cell Culture Flasks Boost your risk-taking abilities withThe precise function of PARK2 is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in PARK2 are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of PARK2 produces multiple transcript variants encoding distinct isoforms. Additional splice variants of PARK2 have