INSI2 Polyclonal Antibody, 100ul Insect Expression detection of CGB1 and CGB2

detection of CGB1 and CGB2 transcripts in vivo

Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS| also known as Gracile Bone Dysplasia)| both characterized by short stature| hypoparathyroidism| bone development abnormalities| and hypocalcemia

RGR may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP

DM1424 & DM1224

and that shares similarity with the intercellular adhesion molecule (ICAM) protein family

INSI2 Polyclonal Antibody, 100ul Insect Expression detection of CGB1 and CGB2The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.